Apotransferrin administration prevents growth ofStaphylococcus epidermidisin serum of stem cell transplant patients by binding of free iron
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منابع مشابه
Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron.
We investigated the effect of free, non-transferrin-bound iron occurring in haematological stem cell transplant patients on growth of Staphylococcus epidermidis in serum in vitro, and prevention of bacterial growth by exogenous apotransferrin. S. epidermidis did not grow in normal serum at inoculated bacterial densities up to 10(3) cfu ml(-1) but slow growth could be detected at higher initial ...
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High-dose chemotherapy of patients with haematological malignancies results in extracellular iron accumulation and appearance of non-transferrin-bound iron, which is thought to predispose the patients to septic infections and contribute to organ toxicity. We describe the development of a human plasma-derived apotransferrin product for iron binding therapy. The product is purified from Cohn frac...
متن کاملA Pharmaceutical Human Apotransferrin Product for Iron Binding Therapy
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The serum iron concentration and Total Iron Binding Capacity (TIBC) status of 24 patients of oral squamous cell carcinoma (OSCC) were compared with the findings of 13 healthy subjects. OSCC was found to have association with low serum iron level. More patients were found to be with significantly lower iron content in serum (p<0.05). But no association between serum TIBC and increased risk of ca...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2003
ISSN: 0928-8244,1574-695X
DOI: 10.1016/s0928-8244(03)00109-3